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Coronavirus Animal Model for Drug Discovery

As an expert in providing solutions to assist virology and microbiology research, Creative Diagnostics is pleased to announce the launch of its innovative Coronavirus Animal Models to accelerate drug discovery and development efforts for the prevention and treatment coronavirus-related diseases. These new models offer researchers a valuable tool for studying the pathogenesis of the virus, testing potential therapeutic agents, and evaluating vaccine efficacy.

Coronaviruses (CoV) are enveloped, positive, single-stranded RNA viruses that infect humans, monkeys, mice, pigs, cats, dogs, wolves, chickens, cattle and avian vertebrates. The virus enters host cells through the interaction of a spike protein on the viral capsid with a cell surface receptor. However, coronaviruses have crossed the species barrier and caused three serious human respiratory infections in the past 17 years. These include the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and a novel outbreak of coronavirus infection in Wuhan in 2019 (CoVID-2019).

These outbreaks have resulted in severe disease and high mortality, but there is still a lack of effective vaccines and antivirals against coronaviruses. Therefore, there is an urgent need for in-depth studies of the pathogenesis of coronaviruses in animals and for the evaluation of the efficacy and safety of potential vaccines and antiviral therapies.

Although many animal models are available, none fully recapitulates the entire process of human coronavirus infection. Creative Diagnostics is committed to providing innovative solutions for coronavirus research, including the development and use of animal models. These coronavirus animal models offered by Creative Diagnostics include SARS-CoV Virus Intranasal Infection Rhesus Monkey Models, SARS-CoV Virus Intranasal Infection Mouse Models, and SARS-CoV-2 Syrian Hamster Models. These models are invaluable for evaluating pathogenicity, transmissibility, severe pathogenesis mechanisms, and virus-host immune interactions.

In addition, Creative Diagnostics offers a comprehensive range of services to support Coronavirus animal model studies for various aspects of human Coronavirus infection. These services include study design, pathological analysis, immune response profiling, efficacy testing, and data analysis. With extensive industry experience, the Creative Diagnostics research team understands the strengths and weaknesses of each animal model and tailors the models to meet the scientific goals of the researcher.

By providing researchers with reliable and relevant models, Creative Diagnostics hopes to contribute to the development of effective countermeasures against coronavirus infections. The company's expertise in animal modeling and virology ensures that researchers have access to high-quality tools and support for their research endeavors. These models provide a robust and reliable platform for researchers to advance their understanding of coronavirus infections and develop novel countermeasures.

Creative Diagnostics is dedicated to accelerating the progress of its global customers' projects and specializes in the development of animal models for coronavirus infection. To find out more about these new animal models and other products from Creative Diagnostics, please visit https://antiviral.creative-diagnostics.com/coronavirus-animal-model.html.

About Creative Diagnostics

Headquartered in New York, Creative Diagnostics is a consulting and experimental service provider specializing in virology and microbiology. The company provides comprehensive solutions to conquer obstacles in virology and microbiology research, from high-security infrastructure provision, biosafety regulation elucidation, to expert viral system assistance.

Alternariol Test Reagents for Food Safety Detection

Creative Diagnostics, a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples, has announced the launch of a new portfolio of Alternariol Test Reagents to facilitate the accurate and efficient detection of alternariol, including Alternariol Antibodies & Antigens, Alternariol ELISA Kits, and Alternariol Screen Tests.

Mycotoxins are highly toxic compounds produced by fungi and Alternariol is a toxic metabolite of Alternaria fungi. It is a benzochromenone, a 6H-benzo[c]chromen-6-one, substituted with a methyl group in position 1 and hydroxyl groups in positions 3, 7 and 9. This fungi is the major mycotoxin produced by the black mould Alternaria, the most common mould infecting small grains worldwide. It is a metabolite, EC 3.1.1.8 (cholinesterase) inhibitor and mycotoxin and belongs to the phenolic group.

Alternariol is a major contaminant of cereals and fruits. Alternariol was found in 31% of feed and agricultural samples (n = 300) in Europe at concentrations ranging from 6.3 to 1840 μg/kg. Data on the toxicity of alternariol are limited, but it is thought to have a low acute toxicity. In contrast to the results of in vivo studies, there is evidence of genotoxic effects of alternanediol in vitro. In vitro, alternanediol induces several types of DNA damage, including single-stranded DNA breaks (SSB), double-stranded DNA breaks (DSB) and oxidative DNA damage.

More than 70 species of Alternaria mycotoxins have been reported, only some of which have physico-chemical properties. Among the most common toxins in food, alternatodiol (AOH), alternatodiol methyl ether (AME), altenuene (ALT) and tenuazonic acid have been studied. To ensure food safety and protect public health, it is essential to have reliable and sensitive methods for detecting these mycotoxins. Creative Diagnostics’ Alternariol Test Reagents provide researchers, food safety professionals and regulatory agencies with a comprehensive solution for the rapid and accurate detection of Alternariol, including Alternariol Antibodies & Antigens, Alternariol ELISA Kits, and Alternariol Screen Tests.

Creative Diagnostics is committed to developing high quality assays to support the development of mycotoxin detection. These new reagents are specifically designed for use in various analytical techniques, including ELISA, lateral flow immunoassays, and immunoaffinity chromatography. They offer exceptional sensitivity and specificity, allowing the detection of alternariol at low levels, making them ideal for both research and routine testing applications.

By providing these innovative test reagents, Creative Diagnostics empowers food safety scientists and research institutions to effectively monitor and control alternariol contamination in food products, safeguarding public health and maintaining consumer confidence in the food supply. For more information on Creative Diagnostics' Alternariol Test Reagents and other food safety solutions, please visit https://www.creative-diagnostics.com/food-analysis/alternariol.html.

About Creative Diagnostics

Creative Diagnostics is a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples. Its product portfolio covers a wide range of analytes including mycotoxins, drug residues, pesticides, contaminants, food allergens, food pathogens and vitamins. The company also assists customers in the rapid development, manufacture and commercialization of small molecule antigens, antibodies and food safety lateral flow strips for any market segment.

Animal-Derived DNA Residue Assay Kits (qPCR) for Research Applications

Creative Diagnostics, a reagent supplier and developer focused on biologics quality control, announces the launch of its new Animal-Derived DNA Residue Assay Kits (qPCR) for researchers to rapidly detect and quantify residual animal DNA in various samples. These kits offer exceptional specificity and sensitivity, ensuring product safety and compliance in the biopharmaceutical and biotech industries.

Creative Diagnostics has developed a range of host cell DNA assay kits for use in specific cell line expression systems based on rapid qPCR technology, which can be used for highly sensitive, highly accurate detection and quantification of host cell DNA contamination. These residual DNA molecules present in the human body along with biological products can lead to increased risk of carcinogenesis, infection and immunomodulation. The World Health Organisation (WHO) and the European Union (EU) allow residual DNA levels of up to 10 ng/dose and the US Food and Drug Administration (FDA) allows residual DNA levels of up to 100 pg/dose. To meet these requirements, methods with high sensitivity and accuracy are needed to detect and quantify low levels of DNA.

The newly released Animal-Derived DNA Residue Assay Kits utilize advanced qPCR technology to provide rapid and reliable results. By targeting specific animal DNA sequences, these kits enable precise detection and quantification of even trace amounts of residual animal material, minimizing the safety risks of animal-derived components and safeguarding public health. These innovative Animal-Derived DNA Residue Assay Kits, such as the Porcine DNA Residue Assay Kit and the Bovine DNA Residue Assay Kit, are essential tools for ensuring the integrity of biological products such as therapeutic proteins, vaccines, and antibodies.

For example, the Bovine DNA Residue Assay Kit (Cat. No. DDNA-017) is a PCR-based fluorescence probe assay for the quantitative detection of bovine DNA residues in biological samples. Offering high sensitivity and specificity, the kit can rapidly detect bovine DNA at the femtogram level. It includes a bovine DNA quantitative reference standard and is paired with the Creative Diagnostics MagIso™ Animal-derived Biomaterials Residual DNA Extraction Kits (Magnetic Beads) for optimal sample preparation. This assay is ideal for the accurate measurement of bovine DNA residues in various biomaterials, such as membranes, patches, and decellularized matrices.

The ResDetFast™ Human DNA Residue Assay Kit (Cat. No. DDNAF-018) is a rapid and sensitive qPCR assay for the quantitative detection of residual human DNA in biological products. It employs PCR primers and probes targeting conserved human genome sequences and includes a ready-to-use human DNA reference standard. When combined with the Creative Diagnostics Nucleic Acid Extraction or Purification Kit, the assay can detect femtogram levels of human DNA in just 1.5 hours. This kit is specifically designed for the quantitative detection of human host cell DNA in intermediate, semi-finished, and finished biological products.

For more information on custom Animal-Derived DNA Residue Assay Kits (qPCR) or project-specific Host Cell DNA Assay Kit development services, please visit https://qbd.creative-diagnostics.com/products/animal-derived-dna-residue-assay-kits-qpcr-2791.html.

About Creative Diagnostics

Creative Diagnostics is a global leader in the development and manufacturing of innovative tools and reagents for bioprocess impurity analysis. The company offers a comprehensive portfolio of solutions to support researchers in the quality control of biologics and provides biopharmaceutical quality, purity and safety assays, analytical methods and applications for the biotechnology and biopharmaceutical industries.

Respiratory Syncytial Virus Animal Models to Advance RSV Research

As an expert in providing solutions to assist virology and microbiology research, Creative Diagnostics has announced the launch of its advanced Respiratory Syncytial Virus Animal Models for researchers and scientists worldwide focused on advancing RSV research and accelerating the development of effective vaccines and therapeutics against RSV.

Human respiratory syncytial virus (hRSV) is an enveloped, single-stranded, negative-sense RNA virus that represents a significant public health burden in both developing and developed countries. Scientists have made concerted efforts to develop various animal models to study different aspects of hRSV. However, the high specificity of hRSV for the human host has greatly hindered the development of specialized animal models. In addition, because no single animal model reflects all aspects of this viral infection and disease, a variety of models have been used to study RSV, ranging from rodents and small mammals to large animals and non-human primates (NHPs).

With the exception of chimpanzees, nonhuman primates are only partially susceptible to hRSV replication. After infection, nonhuman primates have mild or no clinical signs and generally show mild lung lesions. Cotton rats, mice, ferrets, chinchillas, guinea pigs, hamsters, and newborn lambs are also not susceptible to RSV infection. Additionally, cotton rats and mice have been invaluable in the development of monoclonal antibody prophylaxis for high-risk infants and have provided insights into RSV immunity and pathogenesis.

RSV animal models are important tools for studying the complex dynamics of RSV infection, evaluating potential therapies, and developing effective vaccines. With advanced animal modeling technology and unparalleled infectious disease expertise, Creative Diagnostics provides researchers and scientists with reliable respiratory syncytial virus animal models to facilitate the development of therapies and vaccines. Its team of experts can provide clients with the most appropriate RSV animal model based on the infection to be studied and the proposed research hypothesis.

Creative Diagnostics offers a full range of services to support RSV animal model research, including study design and execution, pathological analysis and immune response profiling, as well as in vivo pharmacokinetic studies and pharmacodynamics/efficacy/toxicity assessments. These RSV animal model services allow scientists to evaluate the immunogenicity and efficacy of potential RSV vaccine candidates in preclinical studies, investigate RSV pathogenesis to identify novel therapeutic targets, and assess the safety and efficacy of antiviral and immunomodulatory compounds.

With extensive expertise in biological research, Creative Diagnostics offers RSV Cotton Rat Models and RSV Mouse Models to advance RSV research, vaccine development, and drug discovery. By providing RSV animal models, Creative Diagnostics aims to help accelerate the development of effective treatments and improve patient outcomes. With this new offering, Creative Diagnostics reinforces its commitment to providing high-quality research tools and services to advance the understanding and treatment of infectious diseases.

For more information on the RSV animal models, please visit https://antiviral.creative-diagnostics.com/respiratory-syncytial-virus-animal-model.html.

About Creative Diagnostics

Headquartered in New York, Creative Diagnostics is a consulting and experimental service provider specializing in virology and microbiology. The company provides comprehensive solutions to conquer obstacles in virology and microbiology research, from high-security infrastructure provision, biosafety regulation elucidation, to expert viral system assistance.

T-2/HT-2 Toxin Test Reagents to Ensure Food Safety

Creative Diagnostics, a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples, has introduced its comprehensive range of T-2/HT-2 Toxin Test Reagents to meet the growing demand for accurate and efficient detection of T-2 and HT-2 mycotoxins, ensuring food safety and consumer protection.

T-2 and HT-2 toxins are type A trichothecene mycotoxins produced by fungi of the genus Fusarium. Since T-2 toxin is readily metabolized to HT-2 toxin and T-2 and HT-2 toxins are often found together in infected grain, the two mycotoxins are often analyzed together. The combination of T-2 and HT-2 affects many crops, especially grains and feeds such as corn, wheat, barley, millet, corn gluten feed, corn gluten meal, corn DDGS and bran.

These mycotoxins can cause illness in animals and humans if diseased grains are consumed. Animals affected by the toxins include swine, dairy cattle, poultry, dogs, cats and horses. Effects of the toxins include digestive disorders, bleeding, edema, oral lesions, dermatitis, and blood disorders. In addition, T-2 toxin is the primary causative toxin in human gastrointestinal toxic leukemia.

As food safety awareness has increased in recent years, the European Union (EU) recommended maximum levels for both toxins in food and feed in 2013. To comply with these EU guidelines, grain must be analyzed accurately and reliably. Creative Diagnostics has developed a robust portfolio of T-2/HT-2 Toxin Test Reagents to detect the presence of T-2 and HT-2 toxins in various food products, empowering laboratory researchers, food manufacturers, and regulatory agencies to safeguard public health.

The product line includes a comprehensive array of reagents, such as T2-toxin ELISA Kits, HT2-Toxin Standard, T-2 Toxin Test, and RHA™ anti-T-2 toxin monoclonal antibody. For example, the T2-toxin ELISA Kit is designed for quantitative measurement of T-2 toxin in feed, and the T-2 Toxin Test can be used for rapid qualitative analysis of T-2 Toxin in grain/feed. These reagents offer exceptional sensitivity and specificity, enabling precise quantification of these toxins in diverse food matrices.

Creative Diagnostics is committed to developing high quality reagents to support the advancement of mycotoxin detection. Through years of research and technical staff experience, Creative Diagnostics has successfully developed a range of antigens and antibodies for use in immunoassays and has established ELISA and lateral flow immunoassay test platforms. As a result, this new product line of T-2/HT-2 Toxin Test Reagents, backed by the company's extensive R&D, can ensure optimal performance and reliable results.

Creative Diagnostics is dedicated to supporting the global food safety community by offering comprehensive solutions for mycotoxin detection and analysis. For more information about the testing products and the company's comprehensive portfolio of food safety solutions, please visit https://www.creative-diagnostics.com/food-analysis/tag-t-2-/-ht-2-toxin-39.htm.

About Creative Diagnostics

Creative Diagnostics is a leading manufacturer and supplier of antibodies, small molecule conjugates and critical assay reagents for the analysis of food, feed, environmental and toxicological samples. Its product portfolio covers a wide range of analytes including mycotoxins, drug residues, pesticides, contaminants, food allergens, food pathogens and vitamins. The company also assists customers in the rapid development, manufacture and commercialization of small molecule antigens, antibodies and food safety lateral flow strips for any market segment.

Mammalian DNA Residue Assay Kits (qPCR) for Enhanced Biopharmaceutical Research

Creative Diagnostics, a reagent supplier and developer focused on biologics quality control, is excited to announce the launch of its Mammalian DNA Residue Assay Kits (qPCR) to the research community for precise and reliable detection and quantification of residual mammalian host cell DNA in biopharmaceutical products, ensuring stringent quality control and regulatory compliance.

Detection of residual DNA in host cells throughout the biopharmaceutical manufacturing process is an important step in ensuring product safety and batch validation. Among the methods for detecting residual DNA, qPCR is considered the most practical method due to its sensitivity, accuracy, precision and time-saving. Creative Diagnostics now offers a comprehensive range of Mammalian DNA Residue Assay Kits (qPCR) to accurately detect and quantify residual mammalian host cell DNA throughout the biopharmaceutical manufacturing process, including the Vero DNA Residue Assay Kit, MDCK DNA Residue Assay Kit, CV-1 DNA Residue Assay Kit, CHO DNA Fragment Residue Assay Kit, and BHK DNA Residue Assay Kit.

For example, the MDCK DNA Residue Assay Kit is based on the principle of the PCR fluorescent probe method for the quantification of MDCK residual DNA in samples, which is fast, specific and reliable with a minimal limit of detection for fg levels. The kit is supplied with a reference standard for the quantification of MDCK DNA and can be used in conjunction with the Creative Diagnostics Host Cell DNA Pretreatment Kit to accurately determine the amount of residual MDCK DNA in biological samples.

Another example is the HEK293 DNA Fragment Residue Assay Kit. Using the PCR fluorescent probe method, four different amplification fragments (75 bp, 122 bp, 244 bp, 562 bp) have been designed to quantitatively analyze the size distribution of residual HEK293 DNA fragments in samples. The kit is supplied with a reference standard for HEK293 DNA quantification. It can be used in combination with the Creative Diagnostics Host Cell DNA Pretreatment Kit to accurately determine the amount of residual HEK293 DNA in biological samples.

By leveraging these advanced assay kits, biopharmaceutical manufacturers can significantly improve their operations by reducing product safety risks associated with residual host cell DNA, improving product quality and consistency, ensuring compliance with stringent regulatory guidelines, and optimizing downstream purification processes. These kits represent a significant advancement in biopharmaceutical quality control, enabling professionals to produce safe and effective products that meet the highest regulatory standards.

Creative Diagnostics is dedicated to supporting the biopharmaceutical industry with comprehensive quality control solutions. The company offers a full range of products and services, including assay kits, reagents and custom services, to meet the diverse needs of researchers and manufacturers. For more information about Mammalian DNA Residue Assay Kits and other product offerings, please visit https://qbd.creative-diagnostics.com/products/mammalian-dna-residue-assay-kits-qpcr-2747.html.

About Creative Diagnostics

Creative Diagnostics is a global leader in the development and manufacturing of innovative tools and reagents for bioprocess impurity analysis. The company offers a comprehensive portfolio of solutions to support researchers in the quality control of biologics and provides biopharmaceutical quality, purity and safety assays, analytical methods and applications for the biotechnology and biopharmaceutical industries.