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New Range of Kits for Advanced Exosome Labeling & Purification

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has announced the launch of its new comprehensive line of kits for Exosome Labeling & Purification. This expansion of the exosome product portfolio provides researchers with new and efficient tools for studying these important extracellular vesicles.

Exosomes play an important role in the development of many known diseases and participate in various physiological and pathological developmental processes of the organism. Exosome carriers combine the advantages of cellular drug delivery and nanotechnology. As a new type of drug delivery carrier with natural properties, it has the ability to cross the biological barrier of the human body. Therefore, the use of exosomes as carriers enables effective and safe drug delivery. It can be delivered to all major systems of the human body, thus becoming a feasible and effective method of treating diseases with a bright future.

To understand the biodistribution and function of exosomes, effective tracking and visualization is essential. CD Bioparticles' new range of exosome labeling and purification kits offers a wide selection of options to meet a variety of experimental needs. These kits utilize different fluorescent dyes for efficient membrane labeling, including DiO-Membrane Exosome Labeling & Purification Kit (CDTE24-005-L), PKH67-Membrane Exosome Labeling & Purification Kit (CDTE24-005-L), and DiR-Membrane Exosome Labeling & Purification Kit (CDTE24-007-L).

For example, the DiR-Membrane Exosome Labeling & Purification Kit efficiently labels exosome membranes with DiR, a near-infrared fluorescent lipophilic carbonyl cyanide widely used as a lipophilic tracer. Excess unbound dye is then rapidly removed by superior spin columns, which separate molecules based on size differences. Removal of contaminants is easier and faster than traditional cleanup methods such as ultracentrifugation and spin filtration. This kit has higher specificity and sensitivity than conventional visible dyes due to better tissue permeability in the NIR and lower autofluorescence of cells and tissues. It can be used to track the migration and distribution of labeled exosomes in vivo in real time.

Another is the DiO-Membrane Exosome Labeling & Purification Kit. The carbonyl cyanine dye DiO is highly lipophilic and is widely used for staining cell membranes. This dye labels cells uniformly by lateral diffusion across the plasma membrane. The fluorescence of free DiO is very weak, but is greatly enhanced by binding to the cell membrane. Additionally, DiO fluoresces green upon excitation with maximum excitation and emission wavelengths of 484 nm and 501 nm, respectively. With highly specific membrane labeling and very low background levels, this kit can be used for most applications where visual tracking of labeled exosomes is required.

CD Bioparticles offers a broad portfolio to support exosome research, including purified exosomes, extraction kits, and tools for exosome capture and quantification. To learn more about solutions for exosome research, please visit https://www.cd-bioparticles.net/products/exosome-labeling-purification.

About CD Bioparticles

CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.

Custom Synthesis Service for Magnetic Sodium Alginate Hydrogel Particles

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles announces its specialized service for custom synthesis and drug encapsulation of Magnetic Sodium Alginate Hydrogel Particles. This new offering allows scientists to synthesize particles of homogeneous size and desired loading such as small molecule drugs, peptides and proteins, applicable in drug delivery, biomedical implants, and tissue engineering.

Alginate is a polysaccharide derived from the cell walls of marine brown algae. The main feature that distinguishes alginate from other natural polysaccharides such as agarose and starch is its polyelectrolyte properties. The carboxyl residues in each monomeric unit are usually neutralized by metal cations. Polymeric alginate salt formed from monovalent cations such as Na+ and K+ can dissociate in water to form highly viscous solutions. Divalent cations such as Ca2+ and Mg2+ render the alginate insoluble and form an elastic hydrogel. In addition, composites containing magnetic particles can further enhance the magnetic response.

Magnetic particles based on sodium alginate have become one of the most popular drug delivery platforms due to their inherent properties, such as polyelectrolyte behavior, excellent biocompatibility, low toxicity, and biodegradability. They are highly attractive in the biomedical field. CD Bioparticles now offers custom synthesis of sodium alginate hydrogel magnetic particles and drug encapsulation services for researchers in the field of drug delivery, biomedical implants, tissue engineering, and regenerative medicine. With years of experience and sophisticated equipment, CD Bioparticles can help scientists to synthesize particles of uniform size and desired loading (e.g., small molecule drugs, peptides and proteins).

This new service line includes the synthesis of sodium alginate hydrogel particles or magnetic sodium alginate hydrogel particles with uniform sizes ranging from 20 to 1000 μm, encapsulation of desired cargoes, and production of other designated magnetic graft sodium alginate hydrogel particles, all QC-tested by microscopy. To initiate a project, CD Bioparticles requires information regarding the desired particle diameter, loading cargo, magnetic particle requirements, any modifications needed, quantity required, and any specific QC material requirements.

CD Bioparticles offers drug targeting and delivery services based on ligand conjugated polymer particles and inorganic particles (e.g., sodium alginate hydrogel particles, magnetic particles, and gold nanoparticles). A variety of small molecule chemotherapeutics, nucleic acid drugs and therapeutic antibodies or proteins can be loaded into the nanoparticle delivery system and CD Bioparticles will make every effort to explore suitable and efficient drug delivery strategies for researchers.

Researchers who are interested in exploring the unique properties of Magnetic Sodium Alginate Hydrogel Particles for their projects, or who would like to discuss their specific requirements with the expert team at CD Bioparticles, please visit https://www.cd-bioparticles.com/services/magnetic-sodium-alginate-hydrogel-particles.html.

About CD Bioparticles

CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.

Exosome Extraction Kits to Support Exosome Research

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, recently announced the availability of its new line of Exosome Extraction Kits, which utilize different separation principles to efficiently extract exosomes from complex samples, providing high-purity and high-quality samples for subsequent exosome research.

Exosomes are small vesicles (30-150 nm) containing RNA and proteins that are secreted by cells. They are found in large quantities in body fluids such as blood, saliva, urine and breast milk. Exosomes are thought to act as intercellular messengers, delivering their effectors or signalling molecules between specific cells. However, the structure of exosomes, their effector composition and the biological pathways in which they participate are currently unknown.

The biological function of exosomes requires the isolation of intact exosome particles. Traditional ultracentrifugation methods are cumbersome and difficult to use with high hardware requirements. CD Bioparticles' Exosome Extraction Kits use optimized components for the extraction of exosomes from cell culture supernatants. Combined with the purification and filtration device, high purity exosome particles can be obtained quickly and efficiently, which can be used for electron microscopy, NTA particle size analysis, nucleic acid analysis, protein analysis, cytological experiments, animal experiments, etc.

For example, the Exosome Secondary Purification Kit (Catalogue: CDE24-085-L) is suitable for further purification of exosomes after post-maturation modification (fluorescence staining, antibody labelling, loading of small molecules, large molecule biocouplers, etc.) or further purification of exosomes obtained by other methods. This kit integrates the molecular SEC principle and multi-mode adsorption function for exosome isolation and secondary purification, which has the advantages of high purity, high recovery, high efficiency in removing impurities, high reproducibility, good exosome integrity, simple operation and low equipment requirements. Separation and purification of exosomes can be completed within 40 minutes. The quality of extracted exosomes is stable and reliable, with low protein contamination, and can be used in downstream biological experiments such as protein extraction and analysis, RNA extraction and analysis, and cell function detection.

Another is the ExoLoad-Exosomal RNA Loading Kit (Catalog:CDE24-090-L). It is a rapid, high-throughput, high-precision product for the concentration of cell supernatant samples, which are concentrated for molecular size exclusion chromatography (SEC) separation. This kit is designed to efficiently introduce small nucleic acids such as siRNA, microRNA and ASO into exosomes through the custom development of an exclusive transit peptide ETP (Exosome Transit Peptide) for exosomes, which can easily and quickly achieve efficient loading of exosomal small nucleic acids, and is used for functional and pharmacological studies of small nucleic acid delivery. It requires only two steps, the whole process takes 3 hours and the uptime is 15 minutes, which is comparable to the performance of electroporation.

For more information about CD Bioparticles' Exosome Extraction Kits and other products, please visit https://www.cd-bioparticles.net/exosome-extraction-kits.

About CD Bioparticles

CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.

Advanced Cellulose Nanoparticles for Multiple Biomedical Applications

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles announces the launch of its new line of Cellulose Nanoparticles, including bacterial cellulose, cellulose nanocrystals and cellulose nanofibrils. These innovative nanomaterials exhibit exceptional mechanical properties, biodegradability, and versatile surface functionality, making them suitable for the preparation of bio-nanocomposites used in antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration.

Cellulose nanoparticles have attracted much attention in recent years due to their impressive mechanical properties and nanoscale size, which results in an extremely high surface area to volume ratio. Chemically, cellulose is a linear homopolymeric glycan consisting of β-D-glucopyranose units linked by β-1,4 glycosidic linkages containing a large number of hydroxyl groups.

These hydroxyl groups and their hydrogen bonding capacity play an important role in crystalline stacking and control important physical properties of these highly cohesive materials. They are well suited for surface functionalization and are ideal for improving the mechanical properties of host materials. In addition, they offer several other advantages such as low cost, low density, renewability, biodegradability, a wide variety of fillers available, low energy consumption, high performance and low abrasiveness during processing. All these characteristics make them suitable for a wide range of applications, such as the preparation of bio-nanocomposites for antimicrobial agents, antifouling, wound healing, drug delivery, tissue engineering and bone regeneration.

Aqueous suspensions of cellulose nanoparticles can be converted into cellulose nanofibres by mechanical treatment or into cellulose nanocrystals by acid hydrolysis of biomass. With sustainable and high-performance solutions for various industries, CD Bioparticles offers a wide range of cellulose nanoparticles including Bacterial Cellulose (BC), Cellulose Nanocrystals (CNCs), and Cellulose Nanofibrils (CNFs), each tailored to specific application requirements. These nanoparticles possess remarkable characteristics, including high strength and modulus, low thermal expansion, and transparency. Their surface functionality enables easy modification, further expanding their application potential.

For example, CD Bioparticles offers a wide range of bacterial cellulose to meet the needs of its customers and also provides medical grade, material grade, food grade bacterial cellulose sheets and commercial bacterial cellulose. As a bio-based material with high purity and unique physicochemical properties, and offering high performance at low cost, BC has been used in a wide range of applications in the food industry, biomedical field, bio-based polymers and nanocomposites preparation and other fields. They are highly biocompatible and biodegradable and are easier to be functionalized. As bacterial cellulose composites with antimicrobial and antibiofilm activity, this natural hydrogel has promising applications.

CD Bioparticles strives to provide researchers and manufacturers with the highest quality Cellulose Nanoparticles for various biomedical applications. For detailed product information, technical support, and ordering information on the CD Bioparticles, please visit https://www.cd-bioparticles.com/products/cellulose-nanoparticles-1133.html.

About CD Bioparticles

CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.

Endotoxin Free Silver Nanoparticles for Advanced Biomedical Research

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles announces the launch of its new line of Endotoxin Free Silver Nanoparticles for biomedical research and bioassay development. These highly purified nanoparticles offer exceptional performance and reliability in various research and commercial applications, such as drug delivery, nanosensors, photothermal therapy, antimicrobial agents, biomedical imaging, catalysis, and tissue engineering.

Silver nanoparticles (AgNPs) are increasingly being used in various fields due to their unique physical and chemical properties, including optical, electrical and thermal properties, high electrical conductivity and biological properties. These applications span the medical, food, healthcare, consumer and industrial sectors, with AgNPs being used as antibacterial agents, coatings for medical devices, optical sensors, anti-cancer agents and more. In particular, their applications in life sciences and medicine focus on exploiting their antibacterial, antifungal, antiviral, anti-inflammatory, anti-cancer and anti-angiogenic properties.

Endotoxin free silver nanoparticles are silver nanoparticles synthesized using a proprietary method that ensures high purity and extremely low levels of endotoxin, making them an important tool for biomedical research and applications. Endotoxin contamination can interfere with biological assays, leading to inaccurate results and compromising the validity of experiments. Endotoxin free silver nanoparticles are characterized by high purity and low endotoxin levels, ideal for use in in vivo studies and clinical trials with a low risk of adverse effects.

CD Bioparticles provides a range of endotoxin free silver nanoparticles with sizes varying from 10 nm to 100 nm. These high-purity (>99%) nanoparticles exhibit low endotoxin levels. For example, the DiagNano™ Silver Nanoparticles, Endotoxin Free, 100 nm (Cat. No. BS-100-EF) are ideal for sensitive applications where minimal levels of contaminants are required, such as cytotoxicity studies, immunological studies and sterility testing. These nanoparticles are also well suited for conjugate development for blotting and electron microscopy applications. They are rigorously manufactured to minimize endotoxin levels, ensuring accurate and reproducible results.

CD Bioparticles offers a diverse range of silver nanoparticles with different surface properties and sizes, and the company's proprietary protocols ensure the production of highly monodisperse nanoparticles with a narrow size distribution. To learn more about the new Endotoxin Free Silver Nanoparticles and other products from CD Bioparticles, please visit https://www.cd-bioparticles.com/products/endotoxin-free-silver-nanoparticles-358.html.

About CD Bioparticles

CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.

Online Ordering System for Improved Customer Experience

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, recently unveiled its significantly enhanced online ordering system. This latest update on the website aims to streamline the ordering process for customers, demonstrating CD Bioparticles' commitment that prioritize customer experience, while also creating greater workflow control, making it more efficient and user-friendly.

Nanotechnology has unlocked groundbreaking advancements in drug delivery, disease diagnostics and laboratory technologies by synthesizing and manipulating substances at the nanoscale. However, industry and research laboratories face challenges in analyzing complex and diverse samples and require sensitive and reliable drug delivery systems to provide consistent results in support of analytical studies and assays. Since its inception, CD Bioparticles has been committed to developing and providing cutting-edge technologies to advance drug discovery and development. To enhance the customer shopping experience and save time when placing orders, CD Bioparticles has deliberately updated the ordering system on its website to make it easier for customers to purchase all types of drug delivery products.

Transparent Pricing & Direct Ordering

Firstly, pricing information is provided on the website in a clear and concise manner, making it easy for customers to compare prices and find their favourite products. Customers now can know the cost in advance and make informed purchasing decisions more efficiently. In addition, customers can order directly from the CD Bioparticles website when they find a product they are looking for. No more waiting for price confirmation, just add items to the cart and proceed to check out.

Account Registration & Guest Checkout

To simplify the shopping process for customers, CD Bioparticles invites all customers to register for an account on the website. With an account, customers can save their preferences, view their order history and enjoy a faster checkout process. Certainly, CD Bioparticles also understands that some customers may not wish to register. Visitors can still shop quickly and efficiently without creating an account.

This update reflects the company’s commitment to providing its customers with the best possible experience, which will significantly improve order accuracy, reduce processing time, and enhance overall customer satisfaction. Additionally, CD Bioparticles believes that its customers will benefit from the many advantages of its enhanced online ordering system, and encourages all customers to explore the new system and experience the difference for themselves.

CD Bioparticles is focused on improving the efficiency and accuracy of drug drug delivery research in the biopharmaceutical industry, delivering faster and more reliable results. To learn more about CD Bioparticles' innovative drug delivery solutions and its newly launched ordering system, please visit https://www.cd-bioparticles.net/.

About CD Bioparticles

CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.

Agonist-Based Adjuvants for Enhanced Vaccine Efficacy

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, is excited to announce the launch of its new line of Agonist-Based Adjuvants to support researchers in various fields, including vaccines and immunotherapeutics. These new adjuvants are designed to significantly accelerate vaccine research and development by enhancing immune responses and improving overall vaccine efficacy.

Adjuvants are components that enhance the immunogenicity of a vaccine when used in conjunction with the vaccine antigen. There is a wide variety of adjuvants, ranging from synthetic small molecule compounds to complex natural extracts and particulate materials. Classical human vaccine adjuvants include aluminium adjuvant, MF59, AS01, AS03, AS04 and CpG ODN 1018, which are widely licensed for use in a variety of vaccines and are known to increase antibody titres and enhance cellular immune responses.

Based on their mechanism of action, adjuvants can be classified as immunostimulants and delivery systems. Immunostimulants act by mechanisms such as targeting the Toll-like receptor (TLR), cyclic guanosine adenosine monophosphate synthase interferon gene stimulator (cGAS-STING) and C-type lectin receptor (CLR). Delivery systems work through mechanisms such as prolonged antigen bioavailability, targeted APC, lymph node transport and antigen cross-presentation. These mechanisms provide multiple options for vaccine development.

Agonist-based adjuvants work by activating specific immune receptors, such as TLRs, RIG-I-like receptors (RLRs), and STING, which are crucial for triggering innate and adaptive immune responses. By targeting these pathways, CD Bioparticles' novel adjuvants help vaccines generate a more robust and long-lasting immune memory, ultimately improving protection against diseases. They are compatible with a variety of vaccine antigens, making them versatile tools for vaccine development.

For example, the RC-529 (Catalog: CDAD24-118-T) is a lipid A mimetic (aminoalkyl glucosaminide 4-phosphate) and an adjuvant with similar efficacy to MPL. RC-529 stimulates the innate immune system by signalling through Toll-like receptor 4. Another is the Recombinant (P. fluorescens) purified tetani toxin C-terminal fragment (Catalog: CDAD24-135-T). In vitro, it is a potent mucosal adjuvant and carrier molecule that generates mucosal antibody responses and/or induces systemic T-cell tolerance to relevant antigens.

CD Bioparticles' latest research has focused on optimizing the design and delivery of agonist-based adjuvants, resulting in improved potency and safety. These agonist-based adjuvants have demonstrated remarkable potential in preclinical studies, which may play a vital role in addressing some of the most pressing challenges in vaccine development, including the need for more effective vaccines against emerging infectious diseases.

CD Bioparticles offers a large selection of research-grade adjuvant products for adjuvant formulation, screening, and optimization. The company is committed to advancing the field of vaccine development and improving global health. For more information about CD Bioparticles and and its agonist-based adjuvants, please visit https://www.cd-bioparticles.net/agonist-based-adjuvants.

About CD Bioparticles

CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.

Endotoxin Free Gold Nanoparticles for Biomedical Research and Bioassay Development

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles announces the availability of its new Endotoxin Free Gold Nanoparticles for biomedical research and bioassay development. These nanoparticles offer exceptional biocompatibility and can meet the stringent requirements of researchers and developers working in a variety of fields, including drug delivery, imaging, sensing, medical diagnostics, and therapeutics.

Endotoxin-free gold nanoparticles are specially engineered gold particles with extremely low levels of endotoxin, a toxic substance produced by certain types of bacteria, the presence of which can interfere with experimental results or damage cells or tissues. These nanoparticles are typically coated with citrate to minimize their interaction with biological systems and increase their biocompatibility. Endotoxin-free gold nanoparticles are widely used in biomedical research and bioassay development.

Committed to providing innovative and high-performance biomaterials, CD Bioparticles offers endotoxin-free gold nanoparticles for research applications requiring minimal levels of contamination, such as cytotoxicity studies, immunological studies and sterility testing. The endotoxin content of all batches has been verified by Limulus amebocyte lysate (LAL) testing. These nanoparticles offer exceptional purity and minimal endotoxin contamination to ensure reliable and reproducible results and are suitable for applications such as drug delivery, imaging, and biosensing.

Endotoxin-free gold nanoparticles from CD Bioparticles are available in a range of sizes from 5 nm to 400 nm. These particles exhibit strong light scattering and absorption in the visible and near-infrared regions, making them ideal for various applications. Their renewable nature, excellent thermal, mechanical, and chemical stability, and low toxicity ensure their versatility and safety. Moreover, the surface chemistry of these nanoparticles can be easily modified with biomolecules like antibodies, aptamers, or peptides, enabling precise targeting of specific cells, tissues, or biomolecules.

CD Bioparticles offers a range of functional group/ligand endotoxin free gold nanoparticles to meet diverse research and diagnostic needs, including citric acid-stabilized endotoxin free gold nanoparticles and tannic acid-stabilized endotoxin free gold nanoparticles. For example, the DiagNano™ Gold Nanoparticles, Endotoxin Free, 100 nm (Cat. No.BG-100-EF) are citric acid-stabilized gold nanoparticles, with a maximum absorbance of 572 nm, supplied in 0.1 mM phosphate-buffered saline. These nanoparticles boast a purity of over 99.0% and are free of extraneous reactants. With endotoxin levels below 0.5 EU/mL, they are ideal for cellular studies and exhibit exceptional protein binding efficiency. To ensure optimal sterility, the nanoparticles are packaged in dust-free containers, maintaining the highest level of cleanliness.

CD Bioparticles is dedicated to supporting researchers and scientists with their material needs by providing innovative products and exceptional services. These biocompatible nanoparticles offer researchers a powerful tool for advancing their work in a variety of fields. For more information about Endotoxin Free Gold Nanoparticles and other products, please visit https://www.cd-bioparticles.com/product/endotoxin-free-gold-nanoparticles-356.html.

About CD Bioparticles

CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.

Stable-Isotope Labeled Particles for Blood Flow Measurement

With years of experience in the pharmaceutical and life science sectors, CD Bioparticles is excited to announce the launch of its new line of Stable-Isotope Labeled Particles to the scientific community, providing scientists and researchers with a powerful tool for a wide range of applications, including regional organ blood flow measurements and particle deposition studies.

Polystyrene particles are prepared by emulsion and emulsion-free polymerization processes and provide a flexible platform for diagnostic and bioseparation applications. Several methods are available for attaching biological ligands to polystyrene particles, including adsorption onto plain polystyrene particles, covalent attachment to surface functionalized particles, and adsorption of ligands of interest onto particles precoated with binding proteins (e.g., streptavidin, protein A, or protein G).

Polystyrene particles have a wide range of applications in scientific research, diagnostics, electronics, pharmaceuticals, and nanotechnology, including latex agglutination assays, lateral flow detection, purification and separation, ion-exchange, and solid phase immunoassays. To help accelerate research for regional organ blood flow measurements and particle deposition studies, CD Bioparticles now offers a wide range of non-radioactive isotope-labeled polystyrene particles.

Stable isotopes are non-radioactive forms of atoms. Although they do not emit radiation, their unique properties allow them to be used in a wide range of applications. CD Bioparticles stable isotope-labeled microspheres are a cost-effective alternative to radioactive and optical microspheres for measuring regional organ blood flow and particle deposition studies. In addition, the high sensitivity of these particles makes them suitable for general applications as well as for measuring low flow states or low flow organs such as skeletal muscle and skin.

These new particles are 15 µm (standard size for blood flow studies) or 10 µm in diameter and are unaffected by irradiation or half-life, ensuring safety. Supplied in 10 mL and 20 mL vials containing approximately 2.5 million spheres per mL, the particles are suspended in normal saline with Tween 80 and 0.01% Thimerosal. In addition, CD Bioparticles offers 10 different stable isotopes for particle labeling (additional labels available upon request), including Samarium Labeled Polystyrene Particles (15 μm and 10 μm, dyed blackberry), Antimony Labeled Polystyrene Particles (15 μm, dyed violet), and Ytterbium Labeled Polystyrene Particles (15 μm and 10 μm, dyed kiwi).

CD Bioparticles is committed to providing high-quality research tools that drive scientific discovery. The company's Stable-Isotope Labeled Particles are the latest addition to its extensive portfolio of innovative products available in a variety of sizes and isotopic compositions to suit various experimental requirements. The company will continue to provide exceptional customer support and technical expertise to ensure the successful implementation of these products in research projects.

For more information on how these new particles can enable scientists to conduct studies with greater precision and safety, please visit https://www.cd-bioparticles.com/products/stable-isotope-labeled-particles-325.html.

About CD Bioparticles

CD Bioparticles is a leading manufacturer and supplier of various nanoparticles, microparticles, and coatings for R&D as well as commercialization across different application areas, including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. The company also offers various custom services, including chemical surface-functionalization, fluorescent modification, antibody immobilization, as well as nucleic acid and oligo conjugation to meet client specifications.

Organoid Construct Kit to Advance Drug Discovery

CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, has announced the launch of its Organoid Construct Kits to the scientific community to facilitate the construction of complex organoid models, enabling researchers to advance drug discovery and development, disease modeling, and personalized medicine.

Organoids are microscopic organ-like structures derived from stem cells that have become powerful tools for studying disease mechanisms, drug efficacy and toxicity. CD Bioparticles now offers a variety of Organoid Construction Kits to simplify the process of generating organoids and enable scientists to accelerate their research. This comprehensive portfolio of Organoid Construction Kits includes Cervical Cancer Organoid Construct Kit, Gastric Cancer Organoid Construction Kit, Intestinal Organoid Construction Kit, Lung Cancer Organoid Construction Kit, and Ovarian Cancer Organoid Construction Kit.

These kits include a complete set of optimized reagents, protocols and technical support to guide users through the entire organoid construction process. For example, the ready-to-use Intestinal Organoid Construction Kit can maximize the the satisfaction of customer’s experimental needs, provide the greatest convenience, and reduce the time spent on non-experimental processes. The Organoid Construction Kit is divided into four modules: Part I: Tissue Dissociation and Organoid Construction; Part II: Organoid Transfer; Part III: Organoid Freezing; and Part IV: Organoid Recovery.

The products provide customers with consumables and reagents needed for the entire experimental process, saving time wasted in purchasing various reagents and consumables. Customers only need to equip the product with routine instruments and consumables to complete the entire experimental process of intestinal cancer organoid construction. With its user-friendly protocol and high-quality components, researchers can now streamline their organoid development process and achieve reproducible results.

The Organoid Construction Kit is the latest addition to CD Bioparticles’ extensive portfolio of drug delivery products and services. The company also offers a wide range of 3D cell culture substrates, engineered tissue scaffolds, and other biomaterials for various applications in drug delivery, diagnostics, and research. With these tools, the company can provide researchers with custom solution to the challenges they often face in creating optimal cell growth environments, acquiring sufficient lab materials, and developing biocompatible support structures for tissue regeneration.

In addition, CD Bioparticles offers specialized delivery techniques, tissue engineering scaffold design and modification, and advanced technology platforms to accelerate research. The new products reflect the company's commitment to providing cutting-edge tools that support scientists in their endeavors to advance biomedical research and empower researchers to explore the complexities of human biology and develop novel therapeutic approaches.

CD Bioparticles is dedicated to delivering quality solutions to meet the evolving needs of the scientific community. For more information about the Organoid Construct Kits, please visit https://www.cd-bioparticles.net/medical-device.

About CD Bioparticles

CD Bioparticles is an established drug delivery company that provides customized solutions for developing and manufacturing novel biocompatible drug delivery systems. It specializes in various formulation and drug delivery technologies, from conventional liposomes and PEGylated liposomes to polymer microspheres and nanoparticles for drug delivery. The company also provides contract research services for drug delivery formulation, formulation feasibility study, process development and scale-up, as well as analytical and non-clinical research services.